Genetic origin of Ecuadorians: Europeans, Amerindians and Afros
DOI:
https://doi.org/10.47464/MetroCiencia/vol32/2/2024/78-82Keywords:
genetic origin, genes and ancestry, ecuadorian population, trihybridsAbstract
This article collects the data and studies carried out to genetically characterize the Ecuadorian population. Some genetic markers have been used to determine the origin of the population as well as its ancestry. We are a trihybrid mestizo population whose origin is Amerindian, European and Afro. Each of these ethnic compositions has common genetic footprints. Reference is made to the usefulness of population studies to determine risks of common diseases. Some ethical discussion points are included.
Downloads
References
Paz-y-Miño C. Genes y Origen de los Ecuatorianos. Editorial Universitaria UTE. 2021; ISBN: 978-9942-843-04-3. Quito.
Zambrano AK, Gaviria A, Cobos-Navarrete S, Gruezo C, Rodríguez-Pollit C, Armendáriz-Castillo I, García-Cárdenas JM, Guerrero S, López-Cortés A, Leone PE, Pérez-Villa A, Guevara-Ramírez P, Yumiceba V, Fiallos G, Vela M, Paz-Y-Miño C. The three-hybrid genetic composition of an Ecuadorian population using AIMs-InDels compared with autosomes, mitochondrial DNA and Y chromosome data. Sci Rep. 2019 Jun 25; 9(1):9247. doi: 10.1038/s41598-019-45723-w. PMID: 31239502; PMCID: PMC6592923.
Zambrano AK, Gaviria A, Vela M, Cobos S, Leone PE, Gruezo C, Fiallo G, García-Cárdenas JM, López-Cortés A, Cabrera-Andrade A, Paz-y-Miño C. Ancestry characterization of Ecuador’s Highland mestizo population using autosomal AIM-INDELs. Forensic Science International: Genetics Supplement Series. 2017. http://dx.doi.org/10.1016/j.fsigss.2017.09.191
Gaviria A, Vela M, Fiallos G, Gruezo C, Cobos S, Builes JJ, Paz-y-Miño C, Zambrano AK. Genetic data for twenty-two autosomal STRs (PowerPlex® Fusion) from Afro-Ecuadorian population. Forensic Science International: Genetics Supplement Series, 2017; Vol 6. 303-304.2017.
Pinotti T, Bergström A, Geppert M, Bawn M, Ohasi D, Shi W, Lacerda DR, Solli A, Norstedt J, Reed K, Dawtry K, González-Andrade F, Paz-Y-Miño C, Revollo S, Cuellar C, Jota MS, Santos JE Jr, Ayub Q, Kivisild T, Sandoval JR, Fujita R, Xue Y, Roewer L, Santos FR, Tyler-Smith C. Y Chromosome Sequences Reveal a Short Beringian Standstill, Rapid Expansion, and early Population structure of Native American Founders. Curr Biol. 2019 Jan 7; 29(1):149-157.e3. doi: 10.1016/j.cub.2018.11.029. Epub 2018 Dec 20. PMID: 30581024.
Jota MS, Lacerda DR, Sandoval JR, Vieira PP, Ohasi D, Santos-Júnior JE, Acosta O, Cuellar C, Revollo S, Paz-Y-Miño C, Fujita R, Vallejo GA, Schurr TG, Tarazona-Santos EM, Pena SDj, Ayub Q, Tyler-Smith C, Santos FR; Genographic Consortium. New native South American Y chromosome lineages. J Hum Genet. 2016 Jul; 61(7):593-603. doi: 10.1038/jhg.2016.26. Epub 2016 Mar 31. PMID: 27030145.
Sandoval JR, Lacerda DR, Jota MMS, Robles-Ruiz P, Danos P, Paz-Y-Miño C, Wells S, Santos FR, Fujita R. Tracing the genetic history of the 'Cañaris' from Ecuador and Peru using uniparental DNA markers. BMC Genomics. 2020 Sep 10; 21(Suppl 7):413. doi: 10.1186/s12864-020-06834-1. PMID: 32912150; PMCID: PMC7488242.
Paz-y-Miño C, Salazar-Ruales C, García-Cárdenas JM, Cabrera-Andrade A, López-Cortés A, Pavón-Realpe VH, Eras E, Rodriguez P C, Domínguez Enríquez JP, Cusco Cuzco CD, Navarrete Socasi DC, Leone PE. Study of the Huntington's disease IT-15 gene in different ethnic groups in Ecuador. Clin Genet. 2017 Nov; 92(5):544-547. doi: 10.1111/cge.13028. Epub 2017 Aug 17. PMID: 28369732.
Paz-y-Miño C, Zambrano AK, Ruiz-Cabezas JC, Armendáriz-Castillo I, García-Cárdenas JM, Guerrero S, López-Cortés A, Pérez-Villa A, Guevara-Ramírez P, Yumiceba V, Leone PE. Characterization of Ancestral Origin of Cystic Fibrosis of Patients with New Reported Mutations in CFTR. Biomed Res Int. 2020 May 29; 2020:9074760. doi: 10.1155/2020/9074760. PMID: 32596391; PMCID: PMC7288203.
Paz-y-Miño C, Burgos G, López-Cortés A, Herrera C, Gaviria A, Tejera E, Cabrera-Andrade A. A study of the molecular variants associated with lactase persistence in different Ecuadorian ethnic groups. Am J Hum Biol. 2016 Nov; 28(6):774-781. doi: 10.1002/ajhb.22865. Epub 2016 May 6. PMID: 27153930.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 César Paz-y-Miño

This work is licensed under a Creative Commons Attribution 4.0 International License.


