Whipple procedure safety: 10 year experience in a third level center
Keywords:
Whipple, Clavien Dindo, Pancreatic cancerAbstract
Background: The Whipple procedure, despite advances in surgery, remains the most complex procedure in general surgery, its main indication is the neoplastic pathology of pancreas, duodenum and bile ducts. This persists as a therapeutic challenge due to its high morbidity and mortality that in our country reaches from 40% to 60% and from 15% to 30%, respectively.
Objective: Determine the safety of performing the Whipple procedure in a third level private institution.
Materials and methods: A retrospective observational study was conducted from 2007 to 2017 at the Hospital Metropolitano, the data collected included: surgical indication, complications, hospital stay, among others; these were analyzed with JASP 0.9.2.0.
Results: We included 30 patients, their mean age was 60.1 years, 95% CI: 39 -79 years; 56% were women and 44% men. The average hospital stay was 15 days with a SD:15 days. The main indications were: adenocarcinoma of the pancreas 33.3%, adenocarcinoma of the Vatter ampulla 16.7% and cholangiocarcinoma 16.7%. According to the Clavien Dindo scale, 76.7% presented complications, however, 59.9% of these were mild. In-hospital mortality reached 6.7%.
Conclusions: We attribute the results shown, among others, to the availability of technical facilities, as well as to the experience of the surgical team, emphasizing the prevention of complications or in the case of occurrence, provide a timely diagnosis and adequate treatment with all the required therapeutic methods.
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References
Mier DGM. Allen Oldfather Whipple: La cirugía y el cirujano. Cir Gen 2002;24(4):9.
Bautista C, Albán J. Fístula aorto-duodenal secundaria, una rara oportunidad para realizar un procedimiento de Whipple. Rev Metro Cienc 2018;26(1):21-26.
Cameron JL, He J. Two thousand consecutive pancreaticoduodenectomies. J Am Coll Surg 2015;220(4):530-536.
Medrano-Guzmán R, Luna-Castillo M, Chable-Puc WJ, García-Ríos LE, González-Rodríguez D, Nájera-Domínguez FI. Morbimortalidad de la pancreatoduodenectomía en pacientes con cáncer de páncreas y tumores periampulares en el Hospital de Oncología del Centro Médico Nacional Siglo XXI de 2008 a 2013. Cir Cir 2018;87(1):1352.
Cho EE, Kurtz J, Borscheidt R, Osman H, Jeyarajah RD. Robotic assisted Whipple procedure. HPB. 2019;21:S186.
Pancreatic Cancer - Cancer Stat Facts [Internet]. [citado 14 de julio de 2019]. Disponible en: https://seer.cancer.gov/statfacts/html/pancreas.html
Cáncer de páncreas - Estadísticas [Internet]. Cancer.Net. 2012 [citado 14 de julio de 2019]. Disponible en: https://www.cancer.net/ es/tipos-de-c%C3%A1ncer/c%C3%A1ncer-de-p%C3%A1ncreas/estad%C3%ADsticas
Bauer TM, Dhir T, Strickland A, Thomsett H, Goetz AB, Cannaday S, et al. Genetic drivers of pancreatic cancer are identical between the primary tumor and a secondary lesion in a long-term (>5 years) survivor after a Whipple procedure. J Pancreat Cancer 2018;4(1):81-87.
SOLCA. Cáncer en Guayaquil. Instituto Oncológico Nacional “Dr. Juan Tanca Marengo”. 2019.
SOLCA. Epidemiologia del cancer en Quito 2006-2010. Quito: Nacional. 2014.
Chávez J, Hoyos S, Duarte Á, Ángel C, Segura Á. Análisis de la mortalidad posoperatoria temprana en una cohorte de 132 pacientes sometidos a cirugía de Whipple en Medellín. REVISAR :8.
Cubillo A, Panchana G. Indice de morbimortalidad en pacientes con cáncer duodenopancreatico sometidos a cirugía de Whipple [Internet]. [Guayaquil]: Universidad Católica de Santiago de Guayaquil; 2018. Disponible en: http://repositorio.ucsg.edu.ec/handle/3317/11404
Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, et al. The Clavien-Dindo classification of Surgical Complications: Five-Year Experience. Ann Surg 2009;250(2):187-96.
Karim SAM, Abdulla KS, Abdulkarim QH, Rahim FH. The outcomes and complications of pancreaticoduodenectomy (Whipple procedure): Cross sectional study. Int J Surg 2018;52:383-387.
Callery MP, Castillo-Angeles M, Kent TS. Chapter 105 - Prevention and management of complications of pancreatic surgery. En: Yeo CJ (ed). Shackelford’s surgery of the alimentary Tract, 2 Volume Set (8th ed) [Internet]. Philadelphia: Content Repository Only!; 2019 [citado 15 de julio de 2019]. p.p.1239-1248. Disponible en: http://www.sciencedirect.com/science/article/pii/B9780323402323001059
Dai J, Jiang Y, Fu D. Reducing postoperative complications and improving clinical outcome: Enhanced recovery after surgery in pancreaticoduodenectomy – A retrospective cohort study. Int J Surg 2017;39:176-81.
Flynn D, Belkin E, Howell DA, Rolshud D, Stefan A. Late Complications of Whipple’s resection: Endoscopic recognition and treatment: 814. Am J Gastroenterol 2018;113:S452.
Zorbas KA, Karachristos A. Early versus late drain removal after Whipple procedure. HPB. 2018;20:S105-6.
Xiong J, Szatmary P, Huang W, de la Iglesia-Garcia D, Nunes QM,
Xia Q, et al. Enhanced recovery after surgery program in patients undergoing pancreaticoduodenectomy: A PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore). 2016;95(18):e3497.
Dilek ON, Ozsay O, Acar T, Gur EO, Celik SC, Cengiz F, et al.
Postoperative hemorrhage complications after the Whipple procedure. Turk J Surg [Internet]. 15 de enero de 2018 [citado 15 de julio de 2019]; Disponible en: http://www.turkjsurg.com/abstract/1550/eng
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Copyright (c) 2019 Frans Serpa, Jorge Albán, Andrea Villarreal, Sofía Zarate

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